KMID : 1188320160100040595
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Gut and Liver 2016 Volume.10 No. 4 p.595 ~ p.603
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Disease Phenotype, Activity and Clinical Course Prediction Based on C-Reactive Protein Levels at Diagnosis in Patients with Crohn¡¯s Disease: Results from the CONNECT Study
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Kwon Jee-Hye
Im Jong-Pil Ye Byong-Duk Cheon Jae-Hee Jang Hyun-Joo Lee Kang-Moon Kim You-Sun Kim Sang-Wook Kim Young-Ho Song Geun-Am Han Dong-Soo Kim Won-Ho Kim Joo-Sung
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Abstract
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Background/Aims:C-reactive protein (CRP) is an easily measured index of disease activity, but its ability to predict clinical course is controversial. We therefore designed a study to determine whether the CRP level at Crohn¡¯s disease (CD) diagnosis is a valuable indicator of the disease phenotype, activity, and clinical course.
Methods:We retrospectively analyzed 705 CD patients from 32 institutions. The patients were classified into two groups according to CRP level. The patients¡¯ demographic and clinical characteristics and their use of immunosuppressive or biological agents were recorded. Disease location and behavior, hospitalization, and surgery were analyzed.
Results:A high CRP was associated with younger age, steroid use, colonic or ileocolonic location, high CD activity index, and active inflammation at colonoscopy (p<0.001). As the disease progressed, patients with high CRP were more likely to exhibit strictures (p=0.027). There were significant differences in the use of 5-aminosalicylic acid, antibiotics, corticosteroids, azathioprine, and infliximab (p<0.001, p<0.001, p<0.001, p<0.001, and p=0.023, respectively). Hospitalization was also more frequent in patients with high CRP.
Conclusions:The CRP level at diagnosis is useful for evaluating the phenotype, activity, and clinical course of CD. Closer follow-up strategies, with early aggressive treatment, could be considered for patients with high CRP.
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KEYWORD
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Crohn disease, C-reactive protein, Clinical course
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